Scalable High-Pressure Liposome Manufacturing System with Genizer Pumps & Lipsome Extruders

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Scalable High-Pressure Liposome Manufacturing with Genizer Pumps & Extruders

Introduction to Liposomes
Liposomes are tiny spherical vesicles made from phospholipid bilayers, which are key components of cell membranes. These bilayers have both hydrophilic (water-attracting) and hydrophobic (water-repelling) ends. In aqueous solutions, the hydrophobic ends naturally come together, forming small, stable liposomes spontaneously.

Gene Delivery and Liposomal Applications
Liposomes with phospholipid bilayers are widely used for gene delivery, allowing DNA, RNA, and other genetic materials to be safely and efficiently transported into target cells. They are also used in vaccine formulation, drug delivery systems, and cosmetic products.

Genizer High-Pressure Pump and Liposome Extruder System
Genizer high-pressure pumps, operating up to 2,000 psi, combined with liposome extruders, provide a scalable, sanitary solution for producing liposomes and lipid nanoparticles (LNPs). The system is made from 316L stainless steel and meets strict pharmaceutical manufacturing standards.


Liposome Manufacturing Extrusion System


How the System Works
The high-pressure pump applies precise pressure to force lipid suspensions through extruder membranes. The liposome extruder pushes the mixture through track-etched filters with defined pore sizes, producing homogeneous liposomes with consistent particle size. Only a few passes are needed to achieve the desired size and quality.

Key Features and Benefits

  • Real-time monitoring of pressure and temperature

  • Easy-to-use PLC touch-screen controls

  • Durable materials including titanium alloy, tungsten carbide, PTFE, and UHMWPE
    These features ensure consistent, reproducible results for both small research-scale batches and larger production volumes.

Applications Across Industries
By combining high-pressure homogenization with membrane extrusion, Genizer systems simplify process optimization, enhance reproducibility, and produce liposomes with uniform size and high encapsulation efficiency. The system is ideal for drug delivery, gene therapy, vaccines, and cosmetic applications, offering a reliable and modern approach to liposome manufacturing.

Contact Us
For more information about Genizer high-pressure pumps and liposome extruders, and how they can improve your liposome production process, please get in touch with us.



Genizer High Pressure Pump and Liposome Extruders

Related Articles

High Pressure Homogenizer Introduction

Using NanoGenizer High Pressure Homogenizers for Nanomaterials and Cell Disruption

Liposome Extruders: What it is, How it works, Advantages, Functions, Mechanisms, and Types

High Pressure Homogenizer vs Liposome Extruder, How to Choose?

High Pressure Homogenization vs Sonication: Which is Better for Your Liquid



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